Wang, Yiwei, Wertheim, David F, Jones, Allan S., Chang, Hsin-I. and Coombes, Allan G. A. (2010) Micro-CT analysis of matrix-type drug delivery devices and correlation with protein release behaviour. Journal of Pharmaceutical Sciences, 99(6), pp. 2854-2862. ISSN (print) 0022-3549Full text not available from this archive.
A series of matrix-type drug delivery devices comprising a continuous phase of microporous poly(epsilon-caprolactone) (PCL) and a dispersed phase of protein particles (gelatin) with defined size ranges (45-90, 90-125 and 125-250 microm) were produced by rapidly cooling suspensions in dry ice followed by solvent extraction from the hardened material. High protein loadings (38-44%, w/w) were achieved and highly efficient protein release (90% of the initial load) was obtained over time periods of 3-11 days depending on particle loading and size range. The duration of protein release was extended from 3 to 11 days by reducing the protein load. Quantitative analysis of Micro-CT images identified a three to four times increase in the population of sub-40 microm pores in those matrices which gave rise to accelerated protein release in 24 h (40% rising to 80%) and reduced duration of protein release (11-3 days). Formation of a high density of channels and fissures (connects) between the particles is indicated, which facilitate fluid ingress and diffusion of solubilised protein molecules. Micro-CT analysis also confirmed the uniformity of particle distribution in the matrices and provided measurements of macroporosity within 5-30% of the theoretical value for materials displaying irregular shaped macropores larger than 90 microm. These findings demonstrate the utility of Micro-CT for optimising the formulation and performance of matrix-type delivery devices for macromolecular entities. (c) 2009 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci.
|Uncontrolled Keywords:||polycaprolactone, microporous, matrix, micro-ct, protein delivery, polymeric scaffolds, permeability|
|Research Area:||Biological sciences|
|Faculty, School or Research Centre:||Faculty of Science (until 2011) > School of Life Sciences
Faculty of Computing, Information Systems and Mathematics (until 2011)
|Depositing User:||Automatic Import Agent|
|Date Deposited:||21 Jan 2010 14:07|
|Last Modified:||04 Oct 2010 10:27|
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