Porakishvili, N., Kulikova, N., Jewell, A.P., Youinou, P.Y., Yong, K., Nathwani, A., Heelan, B., Duke, V., Hamblin, T.J., Wallace, P., Ely, P., Clark, E.A. and Lydyard, P.M. (2005) Differential expression of CD180 and IgM by B-cell chronic lymphocytic leukaemia cells using mutated and unmutated immunoglobulin VH genes. British Journal Of Haematology, 131(3), pp. 313-319. ISSN (print) 0007-1048Full text not available from this archive.
We have studied the surface expression of the Toll-like receptor family member CD 180 on cells from 78 patients with B-chronic lymphocytic leukaemia (B-CLL). B-CLL cells had variable levels of CD 180 expression, but this was always less than that expressed by normal blood B cells and was stable for 24 months. Significantly higher levels of CD 180 were expressed by B-CLL cells with mutated IGVH genes compared with those using unmutated IGVH genes. This was in contrast to the higher levels of expression of surface immunoglobulin M by B-CLL cells using unmutated, rather than mutated IGVH genes. CD 180 was functional on B-CLL cells from some of the patients, as shown by the increased expression of CD 86 following incubation in vitro with anti-CD 180. The differential expression of CD 180 amongst B-CLL patients is one more marker that may define more precisely the different biological properties of this heterogeneous disease.
|Additional Information:||This work was supported by the Leukaemia Research Fund and INTAS EU [grant number 01-2239].|
|Uncontrolled Keywords:||b-cell chronic lymphocytic leukaemia, cd180, toll-like receptor, igvh mutation, toll-like receptors, cd38 expression, rp105, activation, apoptosis, disease, antibodies, phenotype, molecule, reveals|
|Research Area:||Allied health professions and studies
|Faculty, School or Research Centre:||Faculty of Health and Social Care Sciences (until 2013)|
|Depositing User:||Lucinda Lyon|
|Date Deposited:||30 May 2007|
|Last Modified:||29 Jun 2010 09:00|
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