Differential expression of CD180 and IgM by B-cell chronic lymphocytic leukaemia cells using mutated and unmutated immunoglobulin VH genes

Porakishvili, N., Kulikova, N., Jewell, A.P., Youinou, P.Y., Yong, K., Nathwani, A., Heelan, B., Duke, V., Hamblin, T.J., Wallace, P., Ely, P., Clark, E.A. and Lydyard, P.M. (2005) Differential expression of CD180 and IgM by B-cell chronic lymphocytic leukaemia cells using mutated and unmutated immunoglobulin VH genes. British Journal Of Haematology, 131(3), pp. 313-319. ISSN (print) 0007-1048

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Abstract

We have studied the surface expression of the Toll-like receptor family member CD 180 on cells from 78 patients with B-chronic lymphocytic leukaemia (B-CLL). B-CLL cells had variable levels of CD 180 expression, but this was always less than that expressed by normal blood B cells and was stable for 24 months. Significantly higher levels of CD 180 were expressed by B-CLL cells with mutated IGVH genes compared with those using unmutated IGVH genes. This was in contrast to the higher levels of expression of surface immunoglobulin M by B-CLL cells using unmutated, rather than mutated IGVH genes. CD 180 was functional on B-CLL cells from some of the patients, as shown by the increased expression of CD 86 following incubation in vitro with anti-CD 180. The differential expression of CD 180 amongst B-CLL patients is one more marker that may define more precisely the different biological properties of this heterogeneous disease.

Item Type: Article
Additional Information: This work was supported by the Leukaemia Research Fund and INTAS EU [grant number 01-2239].
Uncontrolled Keywords: b-cell chronic lymphocytic leukaemia, cd180, toll-like receptor, igvh mutation, toll-like receptors, cd38 expression, rp105, activation, apoptosis, disease, antibodies, phenotype, molecule, reveals
Research Area: Allied health professions and studies
Cancer studies
Faculty, School or Research Centre: Faculty of Health and Social Care Sciences
Related URLs:
Depositing User: Lucinda Lyon
Date Deposited: 30 May 2007
Last Modified: 29 Jun 2010 09:00
URI: http://eprints.kingston.ac.uk/id/eprint/1074

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