Bridge, Peter D., Wertheim, David, Jackson, Andrew C. and McKenzie, Sheila A. (2005) Pressure oscillation amplitude after interruption of tidal breathing as an index of change in airway mechanics in preschool children. Pediatric Pulmonology, 40(5), pp. 420-425. ISSN (print) 8755-6863Full text not available from this archive.
Bronchodilator reversibility testing using change in airway resistance during interruption (Rint) is feasible in preschool children. Analysis of postocclusion oscillations of the mouth pressure-time transient (Pmo(t)), recorded during airflow interruption, may offer an alternative index of change in airway mechanics. We analyzed Pmo(t) oscillation amplitude in three different ways: 1) difference between the first relative maximum and minimum (AMxMn); 2) detection of the dominant frequency using Fourier analysis (AFS); and 3) curve-fitting based on a mathematical model (ACurv). In 25 asymptomatic asthmatic children, aged 2.5-5.6 years, who had undertaken reversibility testing, the correlation coefficients between baseline Rint and amplitude were: AMxMn r = -0.84, AFS r = -0.82, ACurv r = -0.84. The coefficient of variation (CoV) of readings contributing to baseline Rint measurement, as median (range), was 12% (5-24%), which was not significantly different from AFS or ACurv (P > 0.05). All parameters were significantly different postbronchodilator (P < 0.001). Using the sensitivity index, i.e., the change after intervention divided by the baseline standard deviation, ACurv was the most sensitive and Rint the least sensitive, with median (range) at 2.72 (-0.84 to 12.10) and 1.91 (-1.17 to 9.50), respectively (P = 0.005). Our results suggest that oscillation amplitude analysis may provide a sensitive index of change in airway mechanics in preschool children undertaking bronchodilator reversibility testing.
|Uncontrolled Keywords:||Keywords: interrupter technique, preschool asthma, pressure oscillations, amplitude analysis, bronchodilator response, airway mechanics, asthmatic-children, flow interruption, respiratory mechanics, reference values, resistance, healthy, transients, wheeze|
|Research Area:||Computer science and informatics|
|Faculty, School or Research Centre:||Faculty of Computing, Information Systems and Mathematics (until 2011)|
|Depositing User:||Sue Snelling|
|Date Deposited:||23 May 2007|
|Last Modified:||04 Oct 2010 09:15|
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